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open-access-fMRI-database

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1、1000 Functional Connectomes Project - 1200+ ‘resting state’ functional MRI datasets

http://www.nitrc.org/projects/fcon_1000

2、EEG Database Data Set (Machine Learning Repository)

http://archive.ics.uci.edu/ml/datasets/EEG+Database

3、IBSR - The Internet Brain Segmentation Repository

http://www.cma.mgh.harvard.edu/ibsr/

4、LONI Image Data Archive

http://adni.loni.ucla.edu/

5、OASIS - Open Access Series of (MR) Imaging Studie

http://www.oasis-brains.org/

有了数据库之后,就到了分析工具的环节。普通主流分析工具可参考“静息态(fMRI)数据分析的软件汇总与方法资料分享”http://home.52brain.com/thread-17554-1-1.html,在此不再赘述。以下介绍一些有趣的工具(至少我以前没用过听过:)

1、COMSOL - Multiphysics Modeling and Simulation

http://www.comsol.com/

2、ITK - Insight Segmentation and Registration Toolkit

http://www.itk.org/

3、ImageJ - Image Processing and Analysis in Java (这个好像听灵犀提过^_^)

http://rsbweb.nih.gov/ij/

4、MeshLab - processing and editing of unstructured 3D triangular meshe

http://meshlab.sourceforge.net/

5、MIPAV - Medical Image Processing, Analysis and Vizualization

http://mipav.cit.nih.gov/

6、Osirix - Advanced open-source PACS workstation DICOM viewer

http://www.osirix-viewer.com/AboutOsiriX.html

7、Sage: Open Source Mathematics Software

http://www.sagemath.org/

8、Shogun - A Large Scale Machine Learning Toolbox (with Matlab, R, Python interface)

http://www.shogun-toolbox.org/

neuroimage special issue

http://www.sciencedirect.com/science/journal/10538119/124/part/PB?sdc=1

The Human Connectome Project

1,200 healthy adults, twins and their non-twin siblings
Diffusion imaging, Resting-state fMRI, Task-fMRI, magnetoencephalography (MEG), electroencephalography (EEG), Behavioral testing
http://humanconnectome.org/

2,The PING Data Resource
The Data Resource includes neurodevelopmental histories, information about developing mental and emotional functions, multimodal brain imaging data, and genotypes for well over 1000 children and adolescents between the ages of 3 and 20.
http://pingstudy.ucsd.edu/

3, 1000 Functional Connectomes (FCP)
Raw resting state functional MRI and structural MRI for more than 1200 healthy individuals from 33 different contributors
http://fcon_1000.projects.nitrc.org/

4, OpenFMRI
Raw and preprocessed data along with behavioral data for a variety of different task-based functional MRI experiments
https://openfmri.org/

5, Philadelphia Neurodevelopmental Cohort
Raw structural MRI, diffusion MRI, task functional MRI, resting state fMRI, cerebral blood flow, neuropsychiatric assessment, genotyping, and computerized neurocognitive testing data for 1445 individuals, 8-21 years old, including healthy controls and individuals with a variety of diagnoses
http://www.med.upenn.edu/bbl/projects/pnc/PhiladelphiaNeurodevelopmentalCohort.shtml

6, LONI Laboratory of Neuro Imaging
structural MRI Diffusion imaging, Resting-state fMRI, Task-fMRI, magnetoencephalography (MEG), electroencephalography (EEG), PET
http://www.loni.usc.edu/

7, NeuroInformatics DataBase, NIDBAn open-source database platform for archiving, analysis, and sharing of neuroimaging data. Data from the multi-site projects Autism Brain Imaging Data Exchange (ABIDE), Bipolar–Schizophrenia Network on Intermediate Phenotypes parts one and two (B–SNIP1, B–SNIP2), and Monetary Incentive Delay task (MID) are available for download from the public instance of NiDB, with more projects sharing data as it becomes available.
http://nidb.sourceforge.net/

8, OMEGA: The Open MEG Archive
The Open MEG Archive (OMEGA) contains MEG data in raw and processed form and anatomical MRI volumes, demographic and questionnaire information, and eventually will feature other forms of electrophysiological data (e.g., EEG, field and cell recordings).
http://www.mcgill.ca/bic/resources/omega

9, The Center for Integrated Molecular Brain Imaging (Cimbi) databaseComprehensive and unique neuroimaging repository of the serotonin system; Includes ~ 2000 well-characterized healthy volunteers and patients; Multitude of additional data, such as genetic, biochemical and neuropsychological; Associated biobank with blood/saliva samples from most individuals.
https://cimbi.dk/index.php/documents/viewcategory/4-cimbi-database

10, The Open Access Series of Imaging Studies (OASIS)
A project aimed at making MRI data sets of the brain freely available to the scientific community.
http://www.oasis-brains.org/app/template/Index.vm

from openMorph
openMorph

Curated list of open-access databases with human structural MRI data.

Feel free to make additions/updates via pull requests!

For an overview of benefits and considerations related to using open-access data for brain morphology research, see Madan (2017) Front Hum Neurosci [10.3389/fnhum.2017.00405].

ADNI

Alzheimer’s Disease Neuroimaging Initiative
http://adni.loni.usc.edu
older adults; dementia; longitudinal
T1, T2, DTI, ASL, rs-fMRI
Mueller et al. (2005) Alzheimers Dement [10.1016/j.jalz.2005.06.003]
Jack et al. (2008) J Magn Reson Imaging [10.1002/jmri.21049]
ABIDE

Autism Brain Imaging Data Exchange
http://fcon_1000.projects.nitrc.org/indi/abide/
N=1112
developmental; autism
T1, rs-fMRI
Di Martino et al. (2014) Mol Psychiatry [10.1038/mp.2013.78]
ADHD-200

http://fcon_1000.projects.nitrc.org/indi/adhd200/
N=973
developmental; ADHD
T1, rs-fMRI
ADHD-200 Consortium (2012) Front Syst Neurosci [10.3389/fnsys.2012.00062]
Bellec et al. (2017) NeuroImage [10.1016/j.neuroimage.2016.06.034]
Age-ility

http://www.nitrc.org/projects/age-ility/
N=131
T1, dMRI, rs-fMRI, EEG
Karayanidis et al. (2016) [10.1016/j.neuroimage.2015.04.047]
AIBL

Australian Imaging, Biomarkers and Lifestyle
http://www.aibl.csiro.au
N=1100
older adults; dementia; longitudinal
T1, PD, T2, DWI, FLAIR, SWI
Ellis et al. (2009) Int Psychogeriatr [10.1017/S1041610209009405]
BRAINS

Brain Images of Normal Subjects
http://www.brainsimagebank.ac.uk
lifespan
Job et al. (2017) NeuroImage [10.1016/j.neuroimage.2016.01.027]
CamCAN

Cambridge Centre for Ageing and Neuroscience
https://camcan-archive.mrc-cbu.cam.ac.uk/dataaccess/
N=653
lifespan; behavior
T1, T2, DTI, rs-fMRI, task fMRI
Shafto et al. (2014) BMC Neurol [10.1186/s12883-014-0204-1]
Taylor et al. (2017) NeuroImage [10.1016/j.neuroimage.2015.09.018]
CMI-HBN

Child Mind Institute Healthy Brain Network
http://fcon_1000.projects.nitrc.org/indi/cmi_healthy_brain_network/
N=664 (goal of 10,000)
developmental (aged 5-21)
T1, T2, DKI, rs-fMRI, EEG
Alexander et al. (2017) bioRxiv [10.1101/149369]
COBRE

Center for Biomedical Research Excellence
http://cobre.mrn.org
http://fcon_1000.projects.nitrc.org/indi/retro/cobre.html
N=72 patients, 75 healthy controls
schizophrenia; lifespan
T1; rs-fMRI
CoRR

Consortium for Reliability and Reproducibility
http://fcon_1000.projects.nitrc.org/indi/CoRR/html/
N=1629
young adults; test-retest
T1, rs-fMRI, some DTI
Zuo et al. (2014) Sci Data [10.1038/sdata.2014.49]
DLBS

Dallas Lifespan Brain Study
http://fcon_1000.projects.nitrc.org/indi/retro/dlbs.html
N=315
lifespan; behavior
T1, PET
fBIRN

Function Biomedical Informatics Research Network
http://www.birncommunity.org
schizophrenia; test-retest; traveling subjects
Keator et al. (2016) NeuroImage [10.1016/j.neuroimage.2015.09.003]
GSP

Brain Genome Superstruct Project
http://neuroinformatics.harvard.edu/gsp/
N=1570
young adults; test-retest; behavior
T1, rs-fMRI
Holmes et al. (2015) Sci Data [10.1038/sdata.2015.31]
HCP

Human Connectome Project
http://humanconnectome.org
N=1200
young adults; behavior
T1, T2, rs-fMRI, task fMRI, Q-Ball
Van Essen et al. (2013) NeuroImage [10.1016/j.neuroimage.2013.05.041]
Glasser et al. (2016) Nat Neurosci [10.1038/nn.4361]
IXI

Information eXtraction from Images
http://brain-development.org/ixi-dataset/
lifespan
T1, T2, PD, MRA, DTI
Kirby 21

http://www.nitrc.org/projects/multimodal
N=21
test-retest
T1, T1, DTI, FLAIR, ASL, VASO, rs-fMRI
Landman et al. (2011) [10.1016/j.neuroimage.2010.11.047]
MASSIVE

Multiple Acquisitions for Standardization of Structural Imaging Validation and Evaluation
http://massive-data.org/index.html
N=1
multiple dMRI aquisitions
T1, T2, DWI, FLAIR
Froeling et al. (2016) [10.1002/mrm.26259]
Mindboggle-101

Mindboggle-101 data consist of three data sets:
N=101 individually labeled human brain surfaces and volumes
templates (unlabeled images combining the individual brains, used for registration)
atlases (anatomical labels combining the individual brains, used for labeling)
http://www.mindboggle.info/data.html
Data: https://osf.io/nhtur/; Labels: http://mindboggle.info/labels.html
Klein & Tourville (2012) [10.3389/fnins.2012.00171]
MIRIAD

Minimal Interval Resonance Imaging in Alzheimer's Disease
https://www.ucl.ac.uk/drc/research/methods/miriad-scan-database
N=69
longitudinal
T1
Malone et al. (2013) [10.1016/j.neuroimage.2012.12.044]
MPI-LMBB

MPI-Leipzig Mind-Brain-Body
https://openfmri.org/dataset/ds000221/
https://www.nitrc.org/projects/mpilmbb/
N=320
behavior
T1, T2, DWI, rs-fRMI
Mendes et al. (2017) [10.1101/164764]
MSC

Midnight Scan Club
https://openfmri.org/dataset/ds000224/
N=10
T1, T2, MRA, MRV, rs-fMRI, task fMRI
Gordon et al. (2017) Neuron [10.1016/j.neuron.2017.07.011]
NACC

National Alzheimer's Coordinating Center
https://www.alz.washington.edu
lifespan; dementia; longitudinal
T1, T2, DTI, FLAIR
Morris et al. (2006) [10.1097/01.wad.0000213865.09806.92]
NKIRS

Nathan Kline Institute - Rockland Sample
http://fcon_1000.projects.nitrc.org/indi/enhanced/
N=683 (and counting)
developmental; lifespan; behavior
T1, DTI, rs-fMRI
Nooner et al. (2012) [10.3389/fnins.2012.00152]
OASIS cross-sectional

Open Access Series of Imaging Studies
http://www.oasis-brains.org
N=416
lifespan; dementia; test-retest
T1 only
Marcus et al. (2007) J Cogn Neurosci [10.1162/jocn.2007.19.9.1498]
OASIS longitudinal

Open Access Series of Imaging Studies
http://www.oasis-brains.org
N=150
older adults; longitudinal; dementia
T1 only
Marcus et al. (2010) J Cogn Neurosci [10.1162/jocn.2009.21407]
OpenfMRI

https://www.openfmri.org
75 datasets (and counting)
2600 subjects (and counting)
Please see individual dataset pages for details
Poldrack & Gorgolewski (2017) NeuroImage [10.1016/j.neuroimage.2015.05.073]
Poldrack et al. (2013) Front Neuroinform [10.3389/fninf.2013.00012]
PING

Pediatric Imaging, Neurocognition, and Genetics
http://pingstudy.ucsd.edu
N=1493
developmental; behavior
T1, T2, DTI, and rs-fMRI
Jernigan et al. (2016) NeuroImage [10.1016/j.neuroimage.2015.04.057]
PNC

Philadelphia Neurodevelopmental Cohort
https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000607.v2.p2
N=1445
developmental
T1, DTI, ASL, task fMRI
Satterthwaite et al. (2014) NeuroImage [10.1016/j.neuroimage.2013.07.064]
Satterthwaite et al. (2016) NeuroImage [10.1016/j.neuroimage.2015.03.056]
PTBP

Pediatric Template of Brain Perfusion
https://figshare.com/articles/PTBP_Nifti/1190933
N=210
T1, dMRI, rs-fMRI, ASL
Avants et al. (2015) [10.1038/sdata.2015.3]
SALD

Southwest University Adult Lifespan Dataset
http://fcon_1000.projects.nitrc.org/indi/retro/sald.html
N=494
lifespan
T1, rs-fMRI, task fMRI (subset)
Wei et al. (2017) bioRxiv [10.1101/177279]
SchizConnect

http://schizconnect.org
schizophrenia
T1, T2, DTI, rs-fMRI, task fMRI
Wang et al. (2016) NeuroImage [10.1016/j.neuroimage.2015.06.065]
studyforrest

http://studyforrest.org
N=20
T1, T2, dMRI, SWI, angiography
up to 10+ hours of 7T and 3T fMRI per subject (2h hollywood movie [audio and/or audio-visual], localizers, retinotopic mapping, with simult. cardiac/resp, partially with simult. eyetracking)
extensive movie stimulus annotations
musical education, visual acuity, visual sensitivity
Hanke et al. (2014) [10.1038/sdata.2014.3]
T1-250μm

http://hiresmri.ovgu.de
N=1
T1 (250 μm resolution)
Lüsebrink et al. (2017) Sci Data [10.1038/sdata.2017.32]
Test-Retest Reliability of Brain Volume Measurements

https://openfmri.org/dataset/ds000239/
https://figshare.com/collections/Test_Retest_Reliability_of_Brain_Volume_Measurements/929651
N=3, each scanned 40 times within 31 days
T1
MacLaren et al. (2014) [10.1038/sdata.2014.37]
UK Biobank

http://imaging.ukbiobank.ac.uk
N>10,000 (target=100,000)
lifespan; behavior; health
Miller et al. (2016) [10.1038/nn.4393]
Alfaro-Almagro et al. (2016) [10.1101/130385]

Contributors

Created October 23, 2017
Updated February 11, 2026